Methyl Palmitate, also known as methyl hexadecanoate, is easily soluble in alcohol, acetone, chloroform and benzene, soluble in ether, insoluble in water, used as an emulsifier, wetting agent, stabilizer and enhancer Intermediate of plasticizer; methyl palmitate is a very common substance in nature, and it is the main component of some edible trees and vegetables, medicinal plants, ornamental plants, various wild plants, etc. One of the main components of animal fats, for example, the fatty oil of mole crickets contains a certain amount of methyl palmitate. It is also a raw material for bio-pheromone, biodiesel, and cosmetics (emulsifiers, medicines). Methyl palmitate can transmit pheromone between organisms; it can inhibit the effect of Kupffer cells.
Report 1. A method for extracting and purifying methyl palmitate 112-39-0 from biodiesel is characterized by including the following steps:
1) Add polyvinyl alcohol to deionized water, heat and stir until the polyvinyl alcohol is completely dissolved, then add potassium nitrate solid after cooling down to room temperature, and stir to dissolve to obtain a polyvinyl alcohol-potassium nitrate solution, which is used as an extractant for later use;
2) The vegetable oil containing palmitic acid is subjected to methyl esterification reaction with methanol to obtain biodiesel. The extractant of step 1) is added to the biodiesel, stirred and extracted, and the lower extract phase obtained is subjected to back extraction with petroleum ether, and then left to stand for separation. , The upper petroleum ether phase is separated, and the petroleum ether is evaporated to obtain the oily methyl palmitate.
26g palmitic acid and 38.4g anhydrous methanol were sequentially added to the reaction kettle, and 2.34g cerium phosphotungstate was added as a catalyst. The reaction was heated and refluxed for 4 hours. After the reaction, the unreacted methanol was recovered by distillation under reduced pressure; The methyl ester and solid cerium phosphotungstate catalyst are separated by centrifugation. The upper layer is methyl palmitate. After the methyl palmitate is separated, methyl palmitate is obtained. The palmitic acid conversion rate is 96.61%, and the lower layer is solid phosphotungstic acid. Cerium catalyst, dissolve the separated solid cerium phosphotungstate catalyst with 3.5g deionized water, add hydrochloric acid to prepare the solution pH value<1, and filter to remove the insoluble carbon deposits suspended in the cerium phosphotungstate solution to obtain tungsten phosphate The cerium acid solution is concentrated and crystallized to obtain 2.34 g of solid cerium phosphotungstate, and the solid cerium phosphotungstate is directly used as a catalyst for the next esterification reaction.
CN201811453472.7 discloses the application of methyl palmitate in the preparation of drugs for preventing or treating fatty liver. Compared with the prior art, the present invention finds for the first time that methyl palmitate can be used to prevent or treat fatty liver, especially non-alcoholic fatty liver, with significant effects. Studies have confirmed that methyl palmitate can reduce liver steatosis, inflammation and fibrosis, relieve abnormal accumulation of liver lipids, and reduce oxidative stress.
Isopropyl palmitate (isopropyl hexadecanoate, IPP) is a low-viscosity lipophilic non-ionic surfactant. It is an extremely valuable auxiliary raw material in cosmetics and is used in high-end cosmetics such as creams and hair conditioners. Important additives and active agents. CN201510560031.7 discloses a method for synthesizing isopropyl palmitate, which belongs to the synthetic technical field of ester compounds in organic chemistry. The invention first mixes methyl palmitate and isopropanol in a pipeline mixer in a certain proportion, mixes uniformly and heats to a certain temperature, then enters the continuous reactor with the catalyst attached, and controls the transesterification reaction under a certain pressure. The reaction product methanol is continuously separated. Then the reaction mixture enters the isopropyl ester dealcoholization tower to remove excess isopropanol and methanol generated during the reaction but not removed at a certain pressure and temperature. The tower bottom material is cooled by a heat exchanger as isopropyl palmitate Output of finished ester products. The invention uses the high-purity methyl palmitate obtained through the fractionation process in the process of producing biodiesel as a raw material, and continuously removes the reaction product methanol through continuous catalytic reaction, shortens the process flow, reduces the process energy consumption and raw material consumption, and improves the palm Yield of isopropyl acid and product quality.
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